While CBD and marijuana have been used for centuries for many remedies, the role CBD can play in lessening the severity and number of seizures in those diagnosed with epilepsy came into the spotlight in the early 2000’s. That’s when the Figi family began looking for a way to treat their daughter Charlotte’s seizures. At the time, she was suffering upwards of 300 seizures per week. (8)
The inquiry upon the manner in which THC produces its psychoactive effects on the human body led, in the 1980’s, to the discovery of the endocannabinoid system – a rather loose complex of nerve receptors which under the influence of compounds called cannabinoids trigger many physiological and psychological reactions. Because cannabinoid receptors are present in almost every tissue of a mammal’s body (although they are not limited to mammals), it has wide-ranging influences on the well-being of an organism. Therefore cannabinoids are definitely substances that deserve further attention from scientists.
Most human studies of CBD have been done on people who have seizures, and the FDA recently approved the first CBD-based drug, Epidiolex, for rare forms of epilepsy. Clinical trials for other conditions are promising, but tiny. In one Brazilian study published in 2011 of people with generalized social anxiety disorder, for example, taking a 600-mg dose of CBD (higher than a typical dose from a tincture) lessened discomfort more than a placebo, but only a dozen people were given the pill.
A 2016 study in Molecular and Cellular Biochemistry explored how CBD contributed to the fat browning process. Brown fat is a particular type of fat that works to increase energy expenditure, and it produces heat. This allows brown fat to burn more calories, but adults are mostly composed of white fat. In the study, the following was observed as a result of cannabinoid usage:
The anti-emetic and anti-nausea effect of marijuana is a centuries-old known fact. Nevertheless, as early as twenty years ago, the effect was attributed to the actions of THC. Continuous research into other cannabinoids has proven that many other phytocannabinoids produce the same desired effect. At present, the FDA recommends two drugs featuring cannabinoids, in which CBD has the highest concentration, in the treatment of nausea induced by chemotherapy – nabilone and dronabinol. Though in its infancy, promising studies exist which suggest that one day CBD may be incorporated into cancer therapies.
The company recommends that you take one capsule per serving which, in addition to CBD, provides beneficial cannabinoids various essential minerals, vitamins, and plant waxes that promote a healthy diet. A third-party laboratory tests the products to ensure quality. This product is also certified to ensure optimal oversight during the manufacturing process.
Dietary changes are the most important action individuals can choose to get off the roller coaster. But CBD could lend a hand in the process. A 2018 study showed that the cannabinoids THC, CBD and CBN enhance cells’ ability to take up glucose. And they perform even better than metformin, a common pharmaceutical prescribed to lower elevated blood glucose.
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Under federal law, cannabis (from which both CBD and marijuana are derived) is illegal everywhere, although the laws against it aren’t generally enforced in states that have legalized marijuana. Some manufacturers claim that CBD culled from legally imported industrial hemp, which has little to no THC, is fine to ship across the U.S., but many experts disagree, noting that because hemp comes from the same species as marijuana, cannabis sativa, all CBD falls under the DEA’s Schedule 1 designation. “This creative interpretation of the law runs afoul of reality,” says the Brookings Institution, a Washington, DC, think tank.
Everything you need to know about marijuana (cannabis) Marijuana, or cannabis, is the most commonly used illicit drug in the world. It alters the mood and affects nearly every organ in the body. With at least 120 active compounds, marijuana may have health benefits as well as risks. We describe these, addiction, and withdrawal. Learn more about cannabis here. Read now
Because CBD works with specific neurotransmitters to reduce anxiety and increase the ability to focus, initial studies have shown promise in its ability to increase the quality of life by decreasing the symptoms of ADHD for many sufferers. Much of this research is still in the early phases (with a lot of room to learn more), however, CBD may be worth adding to a daily routine for those frustrated with traditional treatment options.
A study highlighting this was performed approximately one decade ago. The study found a link between IBS sufferers and clinical endocannabinoid deficiency, which relates back to the fact that the system directly impacts intestinal motility and function. When CBD was used to activate and regulate the endocannabinoid system, sufferers of IBS saw significant symptom improvement. (42)
CBD is a chemical found in marijuana. CBD doesn't contain tetrahydrocannabinol (THC), the psychoactive ingredient found in marijuana that produces a high. The usual CBD formulation is oil, but CBD is also sold as an extract, a vaporized liquid and an oil-based capsule. Food, drinks and beauty products are among the many CBD-infused products available online.
‘CBD has proven anti-anxiety effects and may be helpful in depression, based on anecdotal reports,’ says Dr Gordon. ‘I use high CBD prescription cannabis medicine products as part of a mental health protocol with my patients suffering with anxiety and depression. The antidepressant effects of CBD have been shown in animal models, but we now need large, depression-specific studies in humans as the next step.’
People who experience psychosis may produce too much or even too little cannabinoids (from overactive dopamine receptors). CBD is milder than our internal cannabinoids and helps to re-establish a balance of cannabinoids in the brain. CBD also helps lower inflammation, which is often increased in schizophrenia. THC, on the other hand, is stronger than our internal cannabinoids (anandamide and 2-AG), this way potentially triggering psychosis [46, 48].
CBD hemp oil has a number of uses and comes in many forms including capsules, tinctures, sublingual supplements, liquid oil, oil as a paste, sprays, salves, creams and in edible forms, such as candies or sweets. You can also inhale CBD oil from vapor-releasing pens, similar to the technology for e-cigarettes. This variety also provides a lot of controlled flexibility in terms of concentration, making CBD hemp oil useful and desirable for people of all ages, economic means, and personal needs.
There are likely very complex relationships also occurring between various Cannabinoids in Cannabis that may lead to certain medical efficacy. That is important to remember when considering the consumption of products that contain Cannabinoids. There is an attractiveness to isolating a specific chemical, researching it, patenting synthetic derivatives, and marketing specific drugs. That said, the relationships are complex, will likely take years to understand, and many patients I’ve met appear to find the most medical benefit from a diverse group of Cannabinoids whose interactions are not particularly well understand, but the results are hard to argue with.
Success stories like Oliver’s are everywhere, but there’s not a lot of data to back up those results. That’s because CBD comes from cannabis and, like nearly all other parts of the plant, is categorized by the Drug Enforcement Agency (DEA) as a Schedule 1 drug—the most restrictive classification. (Others on that list: heroin, Ecstasy, and peyote.) This classification, which cannabis advocates have tried for years to change, keeps cannabis-derived products, including CBD, from being properly studied in the U.S.
More recent experiments, involving the administration of a part CBD part THC solution, have yielded results that contradict the first supposition. At present, on the evidence that cannabidiol reduces some of the psychoactive effects of tetrahydrocannabinol (acting as a de facto antidepressant), scientists argue that cannabidiol has a holistic but indirect influence on all cannabinoid receptors in the endocannabinoid system. The main consequence of this impact seems to be an increase in the production of endocannabinoids. This is now the prevailing idea that accounts for the mountains of empirical evidence of how the benefits of cannabidiol are expressed at the cellular level.